Should you stand alone?

Sometimes, in life, you will have to make an awesome and most times very hard decision to stand alone. I don't want to go into detail, because I have respect for whom I write. Suffice to say, that we all face a fork in the road and have to make a tough decision to disagree with the ones we love the most. But how? How do you stand alone?...with the ones you love most? What do you say or don't say? How do you respect them when your very disagreement is seen as a disrespect? How do you stand alone, without looking arrogant, or nonchalant?